Sickle Cell

SICKLE CELL ANEMIA

Introduction
Sickle carrell disease is a elementric term for a group of brokertic pains caused by the ?-globin ingredient called reap hook hemoglobin (Hb S) (Kock et al., 2000). The ?-globin gene is located on the short arm of chromosome 11, and it is a member of the globin gene family involved in oxygen transport (Koch et al., 2000). Sickle cubicleular telephone disease is the about common single gene disorder in black Americans, and is also common in persons from Mediterranean countries, Turkey, the Arabian Peninsula, Caribbean, and the Indian subcontinent (Wethers, 2000). It is estimated that more than 50,000 Americans argon affected with sickle cubicle disease, making this disease a one of the most prevalent genetic disorders in the United States (Kock et al., 2000).
There are several forms of sickle cell disease, and the most common forms are sickle cell anemia, the sickle ß-thalassemia syndromes, and hemoglobinopathies (Wethers, 2000). In sickle cell anemia, also called homozygous sickle cell disease (or SS disease), the individual inherits a sickle (S) gene from each parent (Wethers, 2000). In the sickle ß-thalassemias, individuals have a sickle (S) gene and gene for ß-thalassemia (Wethers, 2000).



In hemoglobinopathies or doubly heterozygous sickle cell disease, the sickle (S) gene is associated with another abnormal hemoglobin, such as C, D, G or O (Wethers, 2000). The effects of sickle cell disease vary greatly from one person to the next. just about affected people rarely are ill opus others are frequently hospitalized. In contrast to this disease, there is the author in which an individual carry a normal gene (A) in association with the sickle (S) gene. This carrier state is referred to as a sickle cell trait and these individuals: (i) are protect from malaria infection (Aluoch, 1997), (ii) do not express sickle cell disease unless under unusual circumstances such as marked hypoxia (National Institute of Health [NIH], 1996), and (iii) can pass the...If you exigency to get a full essay, order it on our website: Orderessay



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